A. Unveiling the Mystique of Ashwagandha
B. The Historical Significance of Ashwagandha
C. The Science behind Ashwagandha's Efficacy
A. Definition and Origins of Ashwagandha
B. The Botanical Properties of Ashwagandha
C. Active Compounds in Ashwagandha and their Benefits
III. Health Benefits of Ashwagandha
A. Stress and Anxiety Management with Ashwagandha
B. Boosting Cognitive Function and Memory
C. Supporting Physical Health and Vitality
D. Managing Sleep Disorders and Promoting Quality Sleep
IV. Ashwagandha for Holistic Well-being
A. Balancing Hormones and Reproductive Health
B. Promoting a Healthy Cardiovascular System
C. Managing Inflammatory Conditions and Pain
V. Choosing and Using Ashwagandha Products
A. Different Forms of Ashwagandha Supplements
B. Selecting High-Quality Ashwagandha Products
C. Dosage Recommendations and Usage Guidelines
VI. Precautions and Considerations
A. Consulting with a healthcare professional before starting Ashwagandha
B. Potential allergies or sensitivities to Ashwagandha
D. Interactions with certain medical conditions or medications
E. Monitoring for any adverse effects or discomfort
VII. Incorporating Ashwagandha into Lifestyle
A. Integrating Ashwagandha into a balanced diet
B. Complementing Ashwagandha with exercise and physical activity
C. Practicing stress management techniques alongside Ashwagandha
D. Creating a holistic wellness routine with Ashwagandha
A. Recapitulating the numerous benefits of Ashwagandha
B. Encouraging further research and exploration of Ashwagandha
C. Embracing Ashwagandha as a natural ally for overall well-being
IX. Frequently Asked Questions (FAQs)
I. Introduction
A. Unveiling the Mystique of Ashwagandha
Ashwagandha, also known as "Indian ginseng," has been a cornerstone in traditional Ayurvedic medicine for thousands of years. This wonder herb derives its reputation from its widespread beneficial properties spanning mental, physical, and emotional health.
B. The Historical Significance of Ashwagandha
Its use dates back to the times of ancient India, where it was highly valued for its rejuvenating and life-prolonging characteristics. Revered for its therapeutic properties, Ashwagandha has been an integral part of various medicinal systems worldwide.
C. The Science behind Ashwagandha's Efficacy
Modern scientific studies have started to unravel the secrets behind Ashwagandha's potency. Its main components, like withanolides and alkaloids, have been found to offer a wide range of health benefits. These compounds exert powerful adaptogenic, anti-inflammatory, and antioxidant effects, making Ashwagandha an effective natural remedy for many ailments [3].
II. Understanding Ashwagandha Roots
A. Definition and Origins of Ashwagandha
Ashwagandha, scientifically named Withania somnifera, is a perennial shrub native to India, North Africa, and the Middle East. Its roots and berries have been employed for their medicinal properties [4].
B. The Botanical Properties of Ashwagandha
The plant features small green flowers, ripe red fruit, and bulbous roots, which are particularly rich in active compounds. The roots, often dried and ground into powder, form the primary component of various health supplements [5].
C. Active Compounds in Ashwagandha roots and their Benefits
Ashwagandha's potent benefits come from its rich composition of bioactive compounds. The most significant are withanolides, a group of steroidal lactones, recognized for their anti-inflammatory, anti-cancer, and adaptogenic properties. Other compounds, such as alkaloids and sitoindosides, also contribute to its overall health benefits [6].
III. Health Benefits of Ashwagandha Roots
A. Stress and Anxiety Management with Ashwagandha
Ashwagandha's adaptogenic properties: Adaptogens are unique herbs that enhance the body's resilience to stress. Ashwagandha, being a potent adaptogen, helps balance various bodily processes, mitigating the negative impacts of stress [7].
Reducing cortisol levels for stress relief: Chronic stress can lead to elevated cortisol levels, a hormone linked to various health issues. Ashwagandha's ability to modulate cortisol production helps to combat stress and its associated symptoms.
Promoting relaxation and mental well-being: Regular intake of Ashwagandha is associated with improved mental calmness and increased resistance to stressors, thereby enhancing overall mental well-being [8].
B. Boosting Cognitive Function and Memory
Enhancing neuroprotective properties: Ashwagandha is reported to protect brain cells from harmful free radicals, thus promoting neuro-health.
Improving focus, concentration, and clarity: Studies show that Ashwagandha can enhance cognitive abilities, including attention, focus, and information processing speed.
Combating age-related cognitive decline: Regular Ashwagandha intake has shown potential in delaying or mitigating cognitive impairments associated with aging [9].
C. Supporting Physical Health and Vitality
Boosting energy levels and endurance: Ashwagandha can enhance energy production and improve physical performance, making it popular among athletes [10].
Enhancing athletic performance and muscle strength: Research shows Ashwagandha's effectiveness in improving muscle mass and strength in healthy adults [11].
Promoting overall immune system function: With its potent antioxidant and anti-inflammatory properties, Ashwagandha strengthens the immune system and helps in combating diseases [12].
D. Managing Sleep Disorders and Promoting Quality Sleep
Regulating sleep patterns: Ashwagandha's ability to modulate the body's stress response can aid in regulating sleep patterns and combating insomnia.
Combating insomnia and sleep disturbances: Studies indicate Ashwagandha's effectiveness in managing sleep disorders, primarily by reducing anxiety and promoting relaxation.
Promoting restful and rejuvenating sleep: Ashwagandha supports deep and restorative sleep, thus contributing to overall wellness [13].
IV. Ashwagandha for Holistic Well-being
A. Balancing Hormones and Reproductive Health
Improving libido and sexual function: Ashwagandha has been traditionally used as an aphrodisiac. Modern research suggests its effectiveness in improving sexual desire and function in both men and women.[14]
Enhancing fertility and reproductive vitality: Studies reveal that Ashwagandha can improve sperm quality in men and may influence female fertility positively.[15]
Alleviating symptoms of menopause and PMS: Ashwagandha is reported to reduce menopausal symptoms like hot flashes, mood swings, and insomnia. It's also used to ease PMS symptoms.[16]
B. Promoting a Healthy Cardiovascular System
Lowering blood pressure and cholesterol levels: Ashwagandha has been found to lower blood pressure and decrease cholesterol levels, two key components of cardiovascular health.
Reducing the risk of heart diseases: With its anti-inflammatory and antioxidant properties, Ashwagandha may reduce the risk factors for heart disease.
Supporting overall heart health: By modulating the body's response to stress, Ashwagandha can also contribute to overall heart health. [17]
C. Managing Inflammatory Conditions and Pain
Alleviating joint pain and arthritis: The powerful anti-inflammatory properties of Ashwagandha make it a natural remedy for joint pain and arthritis.
Reducing inflammation in the body: Ashwagandha reduces inflammation by inhibiting the release of pro-inflammatory cytokines, thus assisting in various inflammatory conditions.
Supporting a healthy inflammatory response: By influencing the body's inflammatory response, Ashwagandha aids in managing various inflammatory conditions. [18]
V. Choosing and Using Ashwagandha Products
A. Different Forms of Ashwagandha Supplements
Powdered Ashwagandha: Often mixed in warm milk or tea, Ashwagandha powder is a traditional and versatile form of the herb.
Ashwagandha capsules and tablets: For ease of use and dosage control, many prefer Ashwagandha in capsule or tablet form.
Ashwagandha tinctures and extracts: Ashwagandha tinctures and extracts are highly concentrated forms of the herb, offering potent health benefits.[19]
B. Selecting High-Quality Ashwagandha Products
Identifying reputable brands and certifications: Choosing products from reputable brands with third-party testing and quality certifications can assure product safety and potency.
Checking for purity and potency: A high-quality Ashwagandha supplement should be free from fillers, additives, and allergens. It should also contain a high concentration of withanolides.
Considering organic and sustainably sourced options: Choosing organic and sustainably sourced Ashwagandha ensures the product is free from pesticides and contributes to environmental conservation [20].
C. Dosage Recommendations and Usage Guidelines
Determining optimal dosage based on individual needs: Ashwagandha dosage may vary based on age, health status, and individual needs. Consult a healthcare professional for personalized advice.
Safe usage for adults, children, and pregnant women: Although Ashwagandha is generally safe for adults, its usage in children and pregnant women should be under medical supervision.
Incorporating Ashwagandha into daily routines: Ashwagandha can be easily integrated into daily routines, either through supplementation or by adding the powder to food or drinks [21].
VI. Precautions and Considerations
A. Consulting with a healthcare professional before starting Ashwagandha.
Before starting any new supplement, including Ashwagandha, it's crucial to consult with a healthcare professional. They can provide guidance on proper dosage, potential interactions with other medications, and assess suitability based on individual health conditions [44].
B. Potential allergies or sensitivities to Ashwagandha
Like any substance, Ashwagandha can cause allergic reactions in some people, including itching, swelling, dizziness, and trouble breathing. If you're new to Ashwagandha, it's advisable to start with a small dose to see how your body reacts [45].
C. Avoiding Ashwagandha during pregnancy or breastfeeding.
Despite its many health benefits, Ashwagandha is not recommended during pregnancy due to its potential to induce uterine contractions. Its safety during breastfeeding is also uncertain, hence caution is advised [46].
D. Interactions with certain medical conditions or medications
Ashwagandha can interact with certain medications, such as sedatives, immunosuppressants, and thyroid medications. It may also be contraindicated in individuals with specific health conditions like stomach ulcers, multiple sclerosis, or lupus [47].
E. Monitoring for any adverse effects or discomfort
While Ashwagandha is generally considered safe, some people may experience side effects like upset stomach, nausea, or headache. It's important to monitor any discomfort or adverse effects and discuss them with a healthcare professional [48].
VII. Incorporating Ashwagandha into Lifestyle
A. Integrating Ashwagandha into a balanced diet
Ashwagandha can be easily incorporated into a balanced diet. Ashwagandha powder can be added to smoothies, soups, or even baked goods. Alternatively, it can be consumed as a tea or taken in capsule form [49].
B. Complementing Ashwagandha with exercise and physical activity
Regular exercise, when combined with Ashwagandha supplementation, can enhance benefits such as stress relief, increased energy, and improved physical performance [50].
C. Practicing stress management techniques alongside Ashwagandha
Incorporating stress management techniques such as mindfulness, meditation, or yoga, along with Ashwagandha supplementation, can provide synergistic benefits for managing stress and anxiety [51].
D. Creating a holistic wellness routine with Ashwagandha.
Ashwagandha, with its multifaceted benefits, can be an integral part of a holistic wellness routine that may include a balanced diet, regular exercise, sufficient sleep, and mindfulness practices [52].
VIII. Conclusion
A. Recapitulating the numerous benefits of Ashwagandha.
Ashwagandha is a powerful herb with a long history of use in Ayurvedic medicine. Its wide range of benefits includes stress relief, cognitive enhancement, physical vitality, hormone balance, and support for reproductive, cardiovascular, and immune health[53].
B. Encouraging further research and exploration of Ashwagandha.
Despite the extensive research and impressive benefits of Ashwagandha, there is always room for further exploration. Ongoing studies are likely to uncover even more about this extraordinary herb's healing potentials[54].
C. Embracing Ashwagandha as a natural ally for overall well-being.
Considering its multitude of health benefits and generally good safety profile, Ashwagandha can be embraced as a natural ally for overall well-being. Its adaptogenic, anti-inflammatory, and antioxidant properties make it a valuable supplement for modern life's stresses and challenges [55].
IX. Frequently Asked Questions (FAQs)
Is Ashwagandha safe to use?
Yes, Ashwagandha is generally considered safe for most people. However, individuals with certain medical conditions or those taking specific medications should consult with a healthcare professional before beginning supplementation [22].
Can Ashwagandha interact with medications?
Yes, Ashwagandha may interact with certain medications such as those for diabetes, hypertension, and autoimmune diseases. Therefore, it is crucial to consult with a healthcare professional before starting supplementation if you are on any medications [23].
How long does it take for Ashwagandha to show results?
The effects of Ashwagandha may vary from person to person. Some people may experience immediate benefits, while others may take a few weeks to see significant improvements. Consistent use over a longer period of time is generally recommended for optimal results [24].
Are there any side effects of Ashwagandha?
While Ashwagandha is generally well-tolerated, some people may experience side effects such as gastrointestinal upset, diarrhea, or drowsiness. If you experience any adverse reactions, it is advised to stop using the supplement and consult with a healthcare professional [25].
Can Ashwagandha be used for weight loss?
Ashwagandha has been shown to help manage stress-related weight gain by reducing cortisol levels. However, it should not be used as a standalone treatment for weight loss and should be combined with a balanced diet and regular exercise [26].
Is Ashwagandha suitable for vegetarians and vegans?
Yes, Ashwagandha is a plant-based supplement suitable for vegetarians and vegans. However, it's important to read product labels carefully as some Ashwagandha supplements may contain non-vegan ingredients [27].
Can Ashwagandha help with depression and mood disorders?
Emerging research suggests that Ashwagandha may have potential benefits in managing depression and mood disorders due to its stress-relieving properties. However, it should not replace conventional treatment methods and should be used under the supervision of a healthcare professional [28].
Does Ashwagandha have anti-cancer properties?
Emerging research suggests that Ashwagandha may possess anti-cancer properties, potentially inhibiting cancer cell growth and inducing apoptosis (programmed cell death). However, further research is required, and Ashwagandha should not be used as a substitute for conventional cancer treatments [29].
Can Ashwagandha be used for hair and skin health?
Ashwagandha may contribute to healthier hair and skin due to its potent antioxidant properties that combat oxidative stress—a key contributor to aging and disease. It might also promote collagen production, a crucial protein for skin elasticity. But, more rigorous scientific research is needed to substantiate these claims [30].
What is the recommended duration for Ashwagandha supplementation?
The duration of Ashwagandha supplementation can vary depending on the specific health goals of an individual. Some people might notice improvements in their stress levels and cognitive function after a few weeks of use, while others might require several months of supplementation. However, it's always best to consult with a healthcare professional for personalized advice [31].
Can Ashwagandha be used to manage diabetes
Some studies indicate that Ashwagandha may help lower blood sugar levels and improve insulin sensitivity, suggesting potential benefits for people with diabetes. But again, it should not replace conventional treatments, and individuals with diabetes should consult a healthcare professional before using Ashwagandha [32].
Is Ashwagandha suitable for children?
Ashwagandha might be used for children under certain circumstances and with the guidance of a healthcare professional. It's always best to consult a pediatrician or a trained herbalist before giving any herbal supplements to a child [33].
Does Ashwagandha have any known drug interactions?
Yes, Ashwagandha might interact with several types of medications, including those for diabetes, hypertension, and autoimmune disorders. People taking these medications should consult with a healthcare professional before starting Ashwagandha supplementation [34].
Can Ashwagandha be taken with other herbal supplements?
Ashwagandha can be used in conjunction with other herbal supplements, but it's important to consult with a healthcare professional or a trained herbalist to ensure safety and effectiveness [35].
Is Ashwagandha safe for long-term use?
Ashwagandha is generally considered safe for long-term use. However, as with any supplement, it's best to periodically check with a healthcare professional to assess its ongoing suitability and potential side effects [36].
How does Ashwagandha compare to other adaptogenic herbs?
Ashwagandha is one of many adaptogens—plants that help the body resist different kinds of stress. Each adaptogen has its unique properties and uses. For instance, ginseng is often used for its energy-boosting effects, while Rhodiola rosea is known for improving mental performance under stress. Ashwagandha stands out due to its wide range of benefits, from reducing anxiety and improving sleep to enhancing physical performance [37].
Can Ashwagandha help with digestive issues?
Ashwagandha may benefit the digestive system by reducing inflammation and supporting gut microbiome health. Its stress-reducing properties can also help alleviate stress-induced digestive issues such as irritable bowel syndrome [38].
Is Ashwagandha safe for breastfeeding mothers?
While Ashwagandha is generally considered safe for most people, there isn't enough reliable information about its safety during breastfeeding. As a precaution, it's recommended that breastfeeding mothers avoid using Ashwagandha or consult a healthcare professional before starting any new supplements [39].
Can Ashwagandha help with managing symptoms of ADHD?
Some preliminary research suggests that Ashwagandha might improve attention and impulse control in children with attention deficit hyperactivity disorder (ADHD). However, more research is needed, and it should not replace traditional ADHD treatments [40].
Does Ashwagandha have any anti-aging properties?
Ashwagandha is classified as a Rasayana in Ayurvedic medicine, meaning it's considered a rejuvenating herb. It's high in antioxidants, which help protect against cell damage, a key cause of ageing. Research also indicates it may help reduce inflammation, enhance brain function, and improve sleep—all of which can contribute to a more youthful appearance and disposition [41].
Can Ashwagandha improve thyroid function?
Ashwagandha has been found to stimulate thyroid function and can be helpful in the treatment of hypothyroidism. It's important to note, however, that it should be used under medical supervision, especially in individuals with thyroid disorders, as it may overstimulate the thyroid in some cases [42].
What form of Ashwagandha is most effective - the roots, powder, tea, or pills?"
The effectiveness of Ashwagandha largely depends on the quality of the supplement and how it's processed. Traditionally, the roots are used, and they're often ground into a powder that can be mixed with water or added to food. Extracts in capsules or tablets can also be potent and convenient to use. Tea made from Ashwagandha root is another option, though it may be less concentrated than other forms [43].
References
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S).
Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009). Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules, 14(7), 2373-2393.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255.
Dar, N. J., Hamid, A., & Ahmad, M. (2015). Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and molecular life sciences, 72(23), 4445-4460.
Patel, S. S., Shah, R. S., Goyal, R. K. (2011). Antistress activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacologyonline, 1, 392-401.
Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 1-11.
Biswas, S., Mishra, R., & Bishayee, A. (2018). Chapter 48 - Withania somnifera (Ashwagandha): A Promising Remedy for Cardiovascular Diseases. In Watson, R. R. (Ed.), Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults (pp. 471-481). Academic Press.
Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine, 20(12), 901-908.
Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106.
Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628. References
Gupta, S. K., Dua, A., & Vohra, B. P. (2003). Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Drug Metabolism and Drug Interactions, 19(3), 211-222.
Acharya Balkrishna, M. S., Choudhary, A. K., Tokar, E. J., Walker, N. J., & Sahu, R. P. (2019). Mechanisms of anticarcinogenic properties of Withania species: a comprehensive review. Journal of Traditional and Complementary Medicine.
Lopresti, A. L., Drummond, P. D., & Smith, S. J. (2019). A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males. American journal of men's health, 13(2), 1557988319835985.
Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine, 20(12), 901-908.
Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine, 22(1), 96-106.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255.
Sarris, J., Panossian, A., Schweitzer, I., Stough, C., & Scholey, A. (2011). Herbal medicine for depression, anxiety, and insomnia: a review of psychopharmacology and clinical evidence. European neuropsychopharmacology, 21(12), 841-860.
Winters, M. (2006). Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Alternative Medicine Review, 11(4), 269-277.
Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009). Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules, 14(7), 2373-2393.
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary, and Alternative Medicines, 8(5S).
Udayakumar, R., Kasthurirengan, S., Mariashibu, T. S., Rajesh, M., Anbazhagan, V. R., Kim, S. C., ... & Ganapathi, A. (2010). Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats. International journal of molecular sciences, 10(5), 2367-2382.
Sharma, A., Basu, I., & Singh, S. (2018). Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. The Journal of Alternative and Complementary Medicine, 24(3), 243-248.
Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 3(1), 188-224.
Singh, G., Sharma, P. K., Dudhe, R., & Singh, S. (2010). Biological activities of Withania somnifera. Annals of Biological Research, 1(3), 56-63.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255.
Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 3(1), 188-224.
Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., & Banerjee, G. (2010). In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 24(1), 129-135.
Jahanbakhsh, S. P., Manteghi, A. A., Emami, S. A., Mahyari, S., Sahebkar, A., & Iranshahi, M. (2016). Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial. Complementary therapies in medicine, 27, 25-29.
Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628.
Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 1-11.
Sharma, A., Basu, I., & Singh, S. (2018). Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. The Journal of Alternative and Complementary Medicine, 24(3), 243-248.
Mishra, L. C., Singh, B. B., & Dagenais, S. (2000). Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternative medicine review, 5(4), 334-346.
National Center for Complementary and Integrative Health. (2020). Ashwagandha. U.S. Department of Health and Human Services, National Institutes of Health.
Baniahmad, B., Thind, J., Baniahmad, A., & Withers, M. (2019). Ashwagandha-Induced Liver Injury: A Case Series From Iceland and the U.S. Drug-Induced Liver Injury Network. Liver International.
Gogte, V. M. (2000). Ayurvedic pharmacology and therapeutic uses of medicinal plants (Dravyagunavignyan). Bharatiya Vidya Bhavan, Mumbai, India.
Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., & Zwickey, H. L. (2009). In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Journal of Alternative and Complementary Medicine, 15(4), 423-430.
Bleakney, D. M. (2008). Deconstructing an adaptogen: Eleutherococcus senticosus. Holistic Nursing Practice, 22(4), 220-224.
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: A Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary, and Alternative Medicines, 8(5S).
Shenoy, S., Chaskar, U., Sandhu, J. S., & Paadhi, M. M. (2012). Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists. Journal of Ayurveda and Integrative Medicine, 3(4), 209.
Archana, R., & Namasivayam, A. (1999). Antistressor effect of Withania somnifera. Journal of Ethnopharmacology, 64(1), 91-93.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255.
Kumar, G., Srivastava, A., Sharma, S. K., Rao, T. D., & Gupta, Y. K. (2012). Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study. Indian Journal of Medical Research, 141(1), 100.
Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine, 20(12), 901-908.
Mishra, L. C., Singh, B. B., & Dagenais, S. (2000). Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternative Medicine Review, 5(4), 334-346.